3-Substituted 2-formylquinoxaline 1,4-dioxides
| Autor: | Ronald E. Bambury, M. L. Edwards, H. W. Ritter |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Salmonella Infections
Animal biology Cyclic N-Oxides Chemistry Salmonella paratyphi B Proteus Infections Staphylococcal Infections biology.organism_classification Staphylococcal infections medicine.disease Proteus mirabilis Combinatorial chemistry Mice In vivo Quinoxalines Drug Discovery medicine Animals Molecular Medicine Antibacterial activity |
| Zdroj: | Journal of Medicinal Chemistry. 18:637-639 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00240a027 |
| Popis: | The methylnitrone of 3-methyl-1,4-dioxidoquinoxaline-2-carboxaldehyde (1) has been exceptional antibacterial activity in vivo. Derivatives of 3-hydroxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde and 3-acetoxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde were prepared. Several of these compounds were found to be antibacterial agents of the same order of activity as I. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|