Is local resection sufficient for parathyroid carcinoma?
| Autor: | Ilknur Kepenekci Bayram, Volkan Genç, Salim Ilksen Basceken, Siyar Ersoz, Süleyman Utku Çelik, Yusuf Sevim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Parathyroidectomy medicine.medical_specialty Parathyroid medicine.medical_treatment Thyroid Lobectomy carcinoma Disease-Free Survival surgery medicine Carcinoma Humans Neoplasm Invasiveness parathyroid Neoplasm Metastasis Aged Retrospective Studies Hyperparathyroidism lcsh:R5-920 thyroid lobectomy business.industry Age Factors Retrospective cohort study General Medicine Clinical Science Middle Aged medicine.disease Surgery Endocrine surgery Parathyroid Neoplasms Treatment Outcome Parathyroid carcinoma Thyroidectomy Lymph Node Excision Female business lcsh:Medicine (General) Primary hyperparathyroidism Follow-Up Studies |
| Zdroj: | Clinics, Volume: 70, Issue: 4, Pages: 247-249, Published: APR 2015 Clinics; v. 70 n. 4 (2015); 247-249 Clinics; Vol. 70 Núm. 4 (2015); 247-249 Clinics; Vol. 70 No. 4 (2015); 247-249 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 70, Iss 4, Pp 247-249 |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: Parathyroid carcinoma is a rare malignant disease of the parathyroid glands that appears in less than 1% of patients with primary hyperparathyroidism. In the literature, the generally recommended treatment is en bloc tumor excision with ipsilateral thyroid lobectomy. Based on our 12 years of experience, we discuss the necessity of performing thyroid lobectomy on parathyroid carcinoma patients. RESULTS: Eleven parathyroid carcinoma cases were included in the study. All operations were performed at the Department of Endocrine Surgery at Ankara University Medical School. Seven of the patients were male (63.6%), and the mean patient age was 48.9 ± 14.0 years. Hyperparathyroidism was the most common indication for surgery (n ϝ 10, 90.9%). Local disease was detected in 5 patients (45.5%), invasive disease was detected in 5 patients (45.5%) and metastatic disease was detected in 1 patient (9.1%). The mean follow-up period was 99.6 ± 42.1 months, and the patients' average disease-free survival was 96.0 ± 49.0 months. During the follow-up period, only 1 patient died of metastatic parathyroid carcinoma. CONCLUSION: Parathyroid carcinoma has a slow-growing natural progression, and regional lymph node metastases are uncommon. Although our study comprised few patients, it nevertheless showed that in selected cases, parathyroid carcinoma could be solely treated with parathyroidectomy. |
| Databáze: | OpenAIRE |
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