Cancer-Related Fatigue in Patients With and Survivors of Hodgkin Lymphoma: The Impact on Treatment Outcome and Social Reintegration
| Autor: | Stefanie Kreissl, Peter Moosmann, Teresa Halbsguth, Andreas Engert, Indra Thielen, Julia Meissner, Hans-Henning Flechtner, Michael Fuchs, Corinne Brillant, Karolin Behringer, Oluwatoyin Shonukan, Volker Diehl, Helen Goergen, Horst Müller, Peter Borchmann, Jens Ulrich Rueffer, Richard Greil |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Employment Male Cancer Research medicine.medical_specialty Risk Assessment Severity of Illness Index Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Quality of life Internal medicine Germany Severity of illness Adaptation Psychological medicine Humans 030212 general & internal medicine Survivors Young adult Cancer-related fatigue Fatigue Aged Retrospective Studies business.industry Incidence (epidemiology) Incidence food and beverages Retrospective cohort study Middle Aged Hodgkin Disease Clinical trial Oncology Socioeconomic Factors 030220 oncology & carcinogenesis Chronic Disease Physical therapy Quality of Life Female medicine.symptom business Social Adjustment Cohort study |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(36) |
| ISSN: | 1527-7755 |
| Popis: | Purpose Cancer-related fatigue occurs frequently in patients with Hodgkin lymphoma (HL) and has a major impact on their quality of life. We hypothesized that severe fatigue (sFA) might have an impact on patients’ treatment outcome and social reintegration. Methods Of 5,306 patients enrolled in the German Hodgkin Study Group’s fifth generation of clinical trials in HL (HD13, HD14, and HD15; nonqualified and older [> 60 years] patients excluded), 4,529 provided data on health-related quality of life. We describe sFA (defined as a score ≥ 50 on the 0 to 100 scale from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) before and up to 9 years after therapy and analyze its impact on treatment outcome and social reintegration. Results The proportion of patients reporting sFA was 37% at baseline and ranged from 20% to 24% during follow-up. Baseline sFA was associated with significantly impaired progression-free survival and a trend to impaired overall survival, which can be overcome in patients receiving highly effective HL therapies as applied in our fifth-generation trials. Our analysis revealed a significant negative association of sFA and employment in survivors: 5 years after therapy, 51% and 63% of female and male survivors, respectively, with sFA were working or in professional education, compared with 78% and 90% without sFA, respectively ( P < .001 adjusted for age, sex, stage, baseline employment status, and treatment outcome). sFA was also associated with financial problems and the number of visits to a general practitioner and medical specialists. Conclusion sFA is an important factor preventing survivors from social reintegration during follow-up. This observation underscores the need to address fatigue as a significant diagnosis when treating patients with and survivors of cancer. |
| Databáze: | OpenAIRE |
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