Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women
| Autor: | Susan J. Murdoch, John D. Brunzell, Molly C. Carr, Amir F Ayyobi, Samir S. Deeb |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Genotype chemistry.chemical_compound High-density lipoprotein Internal medicine Cholesterylester transfer protein medicine Humans Taq Polymerase Triglycerides Glycoproteins Analysis of Variance Lipoprotein lipase biology Cholesterol Hypertriglyceridemia Lipase Middle Aged medicine.disease Lipoproteins HDL2 Cholesterol Ester Transfer Proteins Lipoproteins LDL Lipoprotein Lipase Endocrinology Liver chemistry Low-density lipoprotein biology.protein Regression Analysis Female lipids (amino acids peptides and proteins) Hepatic lipase Carrier Proteins Lipoproteins HDL Cardiology and Cardiovascular Medicine Dyslipidemia |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 22:667-673 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Hepatic lipase (HL) and cholesteryl ester transfer protein (CETP) have been independently associated with low density lipoprotein (LDL) and high density lipoprotein (HDL) size in different cohorts. These studies have been conducted mainly in men and in subjects with dyslipidemia. Ours is a comprehensive study of the proposed biochemical determinants (lipoprotein lipase, HL, CETP, and triglycerides) and genetic determinants (HL gene [ LIPC ] and Taq1B) of small dense LDL (sdLDL) and HDL subspecies in a large cohort of 120 normolipidemic, nondiabetic, premenopausal women. HL ( P P =0.006) were independently associated with LDL buoyancy, whereas CETP ( P =0.76) and triglycerides ( P =0.06) were not. The women with more sdLDL had higher HL activity ( P =0.007), lower HDL2 cholesterol ( P LIPC ) T allele ( P =0.034) than did the women with buoyant LDL. The LIPC variant was associated with HL activity ( P P =0.034), and LDL buoyancy ( P =0.03), whereas the Taq1B polymorphism in the CETP gene was associated with CETP mass ( P =0.002) and HDL3 cholesterol ( P =0.039). These results suggest that HL activity and HL gene promoter polymorphism play a significant role in determining LDL and HDL heterogeneity in healthy women without hypertriglyceridemia. Thus, HL is an important determinant of sdLDL and HDL2 cholesterol in normal physiological states as well as in the pathogenesis of various disease processes. |
| Databáze: | OpenAIRE |
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