Epigenetic aspects of multiple sclerosis and future therapeutic options
| Autor: | George E. Barreto, Khosro Jamebozorgi, Eskandar Taghizadeh, Daryoush Rostami, Hosein Pormasoumi, Amirhossein Sahebkar |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis Central nervous system Disease Epigenesis Genetic Pathogenesis 03 medical and health sciences 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting microRNA medicine Humans Epigenetics biology business.industry General Neuroscience Multiple sclerosis General Medicine Genetic Therapy DNA Methylation Multiple Sclerosis Chronic Progressive medicine.disease MicroRNAs 030104 developmental biology medicine.anatomical_structure Histone DNA methylation biology.protein business Neuroscience 030217 neurology & neurosurgery Forecasting |
| Zdroj: | The International journal of neuroscience. 131(1) |
| ISSN: | 1563-5279 |
| Popis: | Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease accompanied by demyelination of neurons in the central nervous system that mostly affects young adults, especially women. This disease has two phases including relapsing-remitting form (RR-MS) by episodes of relapse and periods of clinical remission and secondary-progressive form (SP-MS), which causes more disability. The inheritance pattern of MS is not exactly identified and there is an agreement that it has a complex pattern with an interplay among environmental, genetic and epigenetic alternations. Epigenetic mechanisms that are identified for MS pathogenesis are DNA methylation, histone modification and some microRNAs' alternations. Several cellular processes including apoptosis, differentiation and evolution can be modified along with epigenetic changes. Some alternations are associated with epigenetic mechanisms in MS patients and these changes can become key points for MS therapy. Therefore, the aim of this review was to discuss epigenetic mechanisms that are associated with MS pathogenesis and future therapeutic approaches. |
| Databáze: | OpenAIRE |
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