Single Nucleotide Polymorphisms in β-Carotene Oxygenase 1 are Associated with Plasma Lycopene Responses to a Tomato-Soy Juice Intervention in Men with Prostate Cancer
| Autor: | Steven K. Clinton, Rebecca Mehl, Nancy E. Moran, Amanda E. Toland, Joseph P. McElroy, Jennifer M. Thomas-Ahner, Ken M. Riedl, Jessica Fleming, Elizabeth Grainger, Steven J. Schwartz |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Genotype medicine.medical_treatment Population Medicine (miscellaneous) Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Linkage Disequilibrium Beverages Prostate cancer chemistry.chemical_compound Lycopene Solanum lycopersicum Internal medicine medicine Humans Original Research Article education beta-Carotene 15 15'-Monooxygenase education.field_of_study Nutrition and Dietetics Carotene Prostatic Neoplasms Middle Aged beta Carotene medicine.disease Carotenoids SCARB1 Phytofluene Endocrinology chemistry Soybean Proteins Tomato-Soy Juice |
| Zdroj: | The Journal of Nutrition. 149:381-397 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxy304 |
| Popis: | BACKGROUND: Human plasma and tissue lycopene concentrations are heterogeneous even when consuming controlled amounts of tomato or lycopene. OBJECTIVES: Our objective is to determine whether single nucleotide polymorphisms (SNPs) in or near known or putative carotenoid metabolism genes [β-carotene 15,15’ monooxygenase 1 (BCO1), scavenger receptor class B type 1 (SCARB1), ATP-binding cassette transporter subfamily A member 1 (ABCA1), microsomal triglyceride transfer protein (MTTP), apolipoprotein B-48, elongation of very long chain fatty acids protein 2 (ELOVL2), and ATP-binding cassette subfamily B member 1 (ABCB1), and an intergenic superoxide dismutase 2, mitochondrial-associated SNP] are predictive of plasma lycopene responses to steady state tomato juice consumption. METHODS: Secondary linear regression analyses of data from a dose-escalation study of prostate cancer patients [n = 47; mean ± SEM age: 60 ± 1 y; BMI (in kg/m(2)): 32 ± 1] consuming 0, 1, or 2 cans of tomato-soy juice/d (163 mL/can; 20.6 mg lycopene 1.2 mg β-carotene/can) for 24 ± 0.7 d before prostatectomy were conducted to explore 11 SNP genotype effects on the change in plasma lycopene and plasma and prostate tissue concentrations of lycopene, β-carotene, phytoene, and phytofluene. RESULTS: Two BCO1 SNP genotypes were significant predictors of the change in plasma lycopene, with SNP effects differing in magnitude and direction, depending on the level of juice intake (rs12934922 × diet group P = 0.02; rs6564851 × diet group P = 0.046). Further analyses suggested that plasma β-carotene changes were predicted by BCO1 rs12934922 (P |
| Databáze: | OpenAIRE |
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