Atorvastatin prevents type 2 diabetes mellitus--an experimental study
| Autor: | Aiman Abbas Jafri, M. Aslam, Sri Venkata Madhu, Swapan K Bhattacharya, Vikas Galav |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Diabetes risk Atorvastatin Type 2 diabetes Diabetes Mellitus Experimental Impaired glucose tolerance Insulin resistance Internal medicine Diabetes mellitus medicine Animals Insulin Pyrroles Rats Wistar Triglycerides Pharmacology business.industry Body Weight Type 2 Diabetes Mellitus Glucose Tolerance Test medicine.disease Streptozotocin Lipid Metabolism Rats Endocrinology Cholesterol Diabetes Mellitus Type 2 Heptanoic Acids Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Resistance business medicine.drug |
| Zdroj: | European journal of pharmacology. 728 |
| ISSN: | 1879-0712 |
| Popis: | Recent reports of increased diabetes risk have raised concerns regarding the use of statins. The present study was therefore planned to clarify whether atorvastatin can prevent diabetes development in a rat model of type 2 diabetes mellitus. Eight week old male Wistar rats were randomized into three groups (n = 12 each group). Group A was given standard chow diet, while group B and group C were offered high sucrose diet. In addition to high sucrose diet, group C was given atorvastatin (20mg/kg/day) from beginning of study till 26th week. After 26 weeks, a low dose of streptozotocin (15 mg/kg, i.p.) was given to all 3 groups and further followed for 4 weeks. Oral glucose tolerance tests were done at week 4, 26 and week 30. Development of impaired glucose tolerance at week 26 (16.66% vs 100%, P = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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