New pharmacological insights of Galactia glaucescens
| Autor: | José Carlos Cogo, Yoko Oshima-Franco, Andreia Borges Scriboni, Akila Lara de Oliveira, Tiago Jose Bonomini, Natália Tribuiani, Karina Cogo-Müller, Márcio Galdino dos Santos, João B. Fernandes, Arturo San Feliciano, Isadora Caruso Fontana Oliveira, Felipe Silveira Moreno |
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| Rok vydání: | 2018 |
| Předmět: |
biology
Traditional medicine 010405 organic chemistry Chemistry Myotoxin Organic Chemistry Neurotoxicity Venom Plant Science Jararacussu medicine.disease_cause biology.organism_classification Antimicrobial medicine.disease 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Rutin chemistry.chemical_compound Staphylococcus aureus medicine Bothrops |
| Zdroj: | Natural Product Research. 33:2389-2393 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1443086 |
| Popis: | Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity. Additionally, the antimicrobial potential of HEGg was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains, as well as Rutin was isolated for the first time in this specie using chromatographic and spectroscopic methods and its antiophidian property was assessed. HEGg totally prevents the neurotoxicity and myotoxicity effects caused by B. jararacussu, but did not show any antimicrobial effect. Concluding, HEGg and Rutin were able to counteract the toxic effects of the venom and confirmed the antiophidian potential, but not antimicrobial, of G. glaucescens as an alternative for neutralization of B. jararacussu venom. |
| Databáze: | OpenAIRE |
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