Correlations among age, cytokines, lymphocyte subtypes, and platelet counts in autoimmune thrombocytopenic purpura
| Autor: | Ilza Salamunić, Ana Marušić, Boris Labar, Srđana Čulić |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Lymphocyte adult age autoimmune thrombocytopenic purpura cytokine lymphocyte pediatric Immunophenotyping Immune system Internal medicine medicine Humans Platelet Lymphocytes Child Aged Natural Killer Cell Count Aged 80 and over Purpura Thrombocytopenic Idiopathic Platelet Count business.industry Age Factors Autoantibody Infant Hematology Middle Aged Cytokine medicine.anatomical_structure Endocrinology Oncology Child Preschool Pediatrics Perinatology and Child Health Immunology Cytokines business CD8 |
| Zdroj: | Pediatric Blood & Cancer. 47:671-674 |
| ISSN: | 1545-5017 1545-5009 |
| DOI: | 10.1002/pbc.20999 |
| Popis: | While autoimmune thrombocytopenic purpura is mediated by autoantibodies, accumulating evidence suggests that T helper cells and the cytokines they produce also play a key role. We determined correlations among age, serum cytokine concentrations, circulating lymphocyte, and platelet counts in adult (n=19) and children (n¼ ; 29) with autoimmune thrombocytopenic purpura. Correlations between age and cytokine levels were also assessed in healthy controls (n=50). Significant positive correlations between age and serum levels of interferon-gamma, age and CD4þ ; lymphocytes, age and natural killer cell count were observed in these patients. Absolute lymphocyte and CD8þ ; cell count was significantly inversely correlated with age. In adult patients, a significant inverse correlation between platelet and absolute lymphocyte count was observed. In pediatric patients, an inverse correlation of platelet count with serum concentration of interleukin-3 was recorded. In 50 healthy volunteers there were significant positive correlations between age and interleukin-3, -4, -6, and interferon-gamma, and significantly negative correlations with interleukin-2, tumor necrosis factor-alpha, and interferon-alpha. Additional evaluations are necessary to identify the impact of age-related changes in immune function on the clinical course of autoimmune thrombocytopenic purpura. |
| Databáze: | OpenAIRE |
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