A beneficial effect of oxandrolone in the treatment of Duchenne muscular dystrophy: A pilot study
| Autor: | Julaine Florence, Alan Pestronk, Gerald M. Fenichel, V. D. Robison, V. B. Hemelt |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics medicine.drug_class medicine.medical_treatment Duchenne muscular dystrophy Pilot Projects Muscular Dystrophies Oxandrolone Anabolic Agents Prednisone Internal medicine medicine Humans Child Chemotherapy business.industry Androgen medicine.disease Treatment Outcome Endocrinology El Niño Neurology (clinical) Oxandrolona business Anabolic steroid medicine.drug |
| Zdroj: | Neurology. 48:1225-1226 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.48.5.1225 |
| Popis: | We treated 10 boys with Duchenne muscular dystrophy with oxandrolone, an anabolic steroid, for 3 months. The mean of the changes in the average muscle score was an improvement of 0.315 +/- 0.097. The expected mean change in muscle score after 3 months from natural history data is a loss of 0.1. The difference of 0.415 between the actual and expected values is significant at p < 0.01. This preliminary evidence suggests that oxandrolone treatment may provide a degree of functional benefit for children with Duchenne muscular dystrophy that is similar to that after prednisone administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|