Tissue changes in experimental chronic endogenous hyperlipemia
| Autor: | A. Lazzarini Robertson, L.A. Ehrhart, Antanas Butkus, Irvine H. Page |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
medicine.medical_specialty
Phospholipid Adipose tissue Endogeny Hyperlipidemias Biology Kidney chemistry.chemical_compound Surface-Active Agents Dogs Internal medicine medicine Animals Aorta Phospholipids Triglycerides chemistry.chemical_classification Triglyceride Cholesterol Histocytochemistry Myocardium Fatty Acids Fatty acid Gallbladder General Medicine medicine.disease Lipids Endocrinology medicine.anatomical_structure chemistry Adipose Tissue Liver lipids (amino acids peptides and proteins) Spleen Calcification |
| Zdroj: | Journal of atherosclerosis research. 8(2) |
| ISSN: | 0368-1319 |
| Popis: | Summary Tissue changes produced by Triton-induced hyperlipemia were studied in dogs receiving a stock diet for 6–28 months: (1) Atheromatous plaques or calcification were not observed in these animals. (2) Mobilization of endogenous lipids resulted in diffuse deposition in the reticuloendothelial system, gallbladder and kidney. (3) Serum lipid patterns differed from those following high-cholesterol feeding. Each doubling in normal cholesterol concentration was accompanied by a 3-fold increase in free cholesterol and a 9 to 10-fold elevation in triglyceride. The ratio of total cholesterol to phospholipid, however, did not change. (4) Serum and other tissue fatty acid patterns were markedly changed. Cholesterol ester fatty acids were more affected than those of triglyceride or phospholipid. In general, a shift toward increased saturation of fatty acids took place in all tissues, except adipose. As a result of this change, fatty acid patterns approached those found in normal adipose tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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