Pathogenesis ofHelicobacter pyloriInfection

Autor: Tran Thi Huyen Trang, Yoshio Yamaoka, Dionyssios N. Sgouras
Přispěvatelé: Laboratoire de microbiologie médicale = Laboratory of Medical Microbiology [Athènes], Institut Pasteur Hellénique, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Oita University Faculty of Medicine [Oita, Japon], Department of Medicine‐Gastroenterology [Houston], Baylor College of Medicine (BCM), Baylor University-Baylor University-Michael E. DeBakey Veterans Affairs Medical Center [Houston] (MEDVAMC), This report was based on work supported in part by grants from the National Institutes of Health (DK62813) (YY) and Grants‐in‐Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (25293104, 26640114 and 15H02657) (YY) and the InfeNeutra project, KRIPIS National Strategic Reference Framework (ESPA 2007‐2013, MIS 450598) of the Ministry of Culture and Education of Greece (DS).
Rok vydání: 2015
Předmět:
Zdroj: Helicobacter
Helicobacter, Wiley, 2015, 20 (supp. 1), pp.8-16. ⟨10.1111/hel.12251⟩
ISSN: 1083-4389
1523-5378
DOI: 10.1111/hel.12251
Popis: International audience; Three decades have passed since Warren and Marshall described the successful isolation and culture of Helicobacter pylori, the Gram-negative bacterium that colonizes the stomach of half the human population worldwide. Although it is documented that H. pylori infection is implicated in a range of disorders of the upper gastrointestinal tract, as well as associated organs, many aspects relating to host colonization, successful persistence, and the pathophysiological mechanisms of this bacteria still remain controversial and are constantly being explored. Unceasing efforts to decipher the pathophysiology of H. pylori infection have illuminated the crucially important contribution of multifarious bacterial factors for H. pylori pathogenesis, in particular the cag pathogenicity island (PAI), the effector protein CagA, and the vacuolating cytotoxin VacA. In addition, recent studies have provided insight into the importance of the gastrointestinal microbiota on the cumulative pathophysiology associated with H. pylori infection. This review focuses on the key findings of publications related to the pathogenesis of H. pylori infection published during the last year, with an emphasis on factors affecting colonization efficiency, cagPAI, CagA, VacA, and gastrointestinal microbiota.
Databáze: OpenAIRE
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