Enterovirus D68 serosurvey: evidence for endemic circulation in the Netherlands, 2006 to 2016
Autor: | Dasja Pajkrt, Gerrit Koen, Kimberley S. M. Benschop, Katja C. Wolthers, Eveliina Karelehto, Fiona van der Klis |
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Přispěvatelé: | Graduate School, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, Amsterdam Reproduction & Development (AR&D) |
Rok vydání: | 2019 |
Předmět: |
Adult
0301 basic medicine Adolescent Epidemiology 030106 microbiology Antibodies Viral medicine.disease_cause Disease Outbreaks 03 medical and health sciences Age Distribution Neutralization Tests Seroepidemiologic Studies EV-D68 Virology Genotype Enterovirus Infections Prevalence non-polio enteroviruses medicine Humans Child Aged Netherlands Enterovirus D Human Respiratory illness outbreak Atomic force microscopy business.industry Research enterovirus D-68 Public Health Environmental and Occupational Health Infant Outbreak Middle Aged Antibodies Neutralizing Acute flaccid myelitis 3. Good health picornavirus 030104 developmental biology Child Preschool surveillance acute flaccid myelitis Enterovirus AFM business Enterovirus D68 |
Zdroj: | Eurosurveillance Euro surveillance, 24(35). Centre Europeen pour la Surveillance Epidemiologique du SIDA |
ISSN: | 1560-7917 1025-496X |
Popis: | Background Enterovirus D68 (EV-D68) has caused major outbreaks of severe respiratory illness worldwide since 2010. Aim Our aim was to evaluate EV-D68 circulation in the Netherlands by conducting a serosurvey of EV-D68 neutralising antibodies (nAb) among the Dutch general population. Methods We screened 280 sera from children and adults in the Netherlands and used two independent sets of samples collected in the years 2006 and 2007 and in the years 2015 and 2016, time points before and after the first EV-D68 upsurge in 2010. Neutralisation capacity of the sera was tested against the prototype Fermon EV-D68 strain isolated in 1962 and against a recent EV-D68 strain (genotype B3) isolated in France in 2016. Results Regardless of the time of serum collection, we found remarkably high overall seropositivity (94.3–98.3%) for nAb against both EV-D68 strains. Geometric mean titres increased in an age-dependent manner. Conclusions Our data suggest that EV-D68 has been circulating in the Netherlands for decades and that the enterovirus surveillance does not accurately capture the prevalence of this clinically relevant pathogen. |
Databáze: | OpenAIRE |
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