Roles of Apicomplexan protein kinases at each life cycle stage
| Autor: | Tatsuki Sugi, Tatsuya Iwanaga, Kentaro Kato |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Life Cycle Stages
Plasmodium Kinase medicine.drug_class Protozoan Proteins Biology Protein kinase inhibitor Cell biology Infectious Diseases CDC37 Mitogen-activated protein kinase parasitic diseases biology.protein medicine Animals Parasitology ASK1 c-Raf Protein kinase A Apicomplexa Protein Kinase Inhibitors Protein Kinases Toxoplasma MAPK14 |
| Zdroj: | Parasitology International. 61:224-234 |
| ISSN: | 1383-5769 |
| Popis: | Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma. |
| Databáze: | OpenAIRE |
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