Host Epigenetic Alterations and Hepatitis B Virus-Associated Hepatocellular Carcinoma
| Autor: | Francesca Guerrieri, Mirjam B. Zeisel, Massimo Levrero |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
virus–host interactions
Review medicine.disease_cause Virus epigenetic regulation 03 medical and health sciences 0302 clinical medicine Gene expression medicine Epigenetics epidrugs 030304 developmental biology Hepatitis B virus 0303 health sciences business.industry General Medicine hepatocellular carcinoma medicine.disease digestive system diseases HBx Viral replication Drug development 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Medicine business hepatitis B virus |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 1715, p 1715 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of the liver and a leading cause of cancer-related deaths worldwide. Although much progress has been made in HCC drug development in recent years, treatment options remain limited. The major cause of HCC is chronic hepatitis B virus (HBV) infection. Despite the existence of a vaccine, more than 250 million individuals are chronically infected by HBV. Current antiviral therapies can repress viral replication but to date there is no cure for chronic hepatitis B. Of note, inhibition of viral replication reduces but does not eliminate the risk of HCC development. HBV contributes to liver carcinogenesis by direct and indirect effects. This review summarizes the current knowledge of HBV-induced host epigenetic alterations and their association with HCC, with an emphasis on the interactions between HBV proteins and the host cell epigenetic machinery leading to modulation of gene expression. |
| Databáze: | OpenAIRE |
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