Abnormalities of the Bronchial Arteries in Asthma
Autor: | John C. Butt, Alan James, N. Carroll, Francis H. Y. Green |
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Rok vydání: | 2006 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Adolescent Status Asthmaticus Tracheobronchial lymph nodes Lumen (anatomy) Arterial Occlusive Diseases Bronchial Arteries Critical Care and Intensive Care Medicine Muscle Smooth Vascular Death Sudden Sex Factors Reference Values Risk Factors medicine.artery Internal medicine medicine Fibromuscular Dysplasia Humans Asthma business.industry Smoking Respiratory disease Age Factors Case-control study Calcinosis Middle Aged Elastic Tissue medicine.disease Pathophysiology respiratory tract diseases medicine.anatomical_structure Case-Control Studies Cardiology Female Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine Bronchial artery business Cell Division Artery |
Zdroj: | Chest. 130:1025-1033 |
ISSN: | 0012-3692 |
DOI: | 10.1378/chest.130.4.1025 |
Popis: | The bronchial arteries supply systemic blood to the airways, tracheobronchial lymph nodes, and nerves. Their structure has not been studied in patients with asthma.Case-control study of pathologic changes of bronchial arteries in asthma.Postmortem lungs were examined from three case groups: (1) fatal asthma (n = 12), death due to asthma; (2) nonfatal asthma (n = 12), asthmatic and death due to nonrespiratory causes; and (3) nonasthmatic control subjects (n = 12), no history of asthma and death due to nonrespiratory causes. In bronchial arteries with outer diameters of 0.1 to 1.0 mm, the areas of lumen, intima, and media were measured and compared between case groups.There were no significant differences in artery size (outer diameter) or in medial area between the three groups. In the two asthma groups, the intimal area was increased (p0.05), with a corresponding decrease in luminal area compared with the control group. There was a significant effect of gender, age, and smoking on intimal area. In the asthma cases, the area of bronchial artery intima was related to duration of asthma (p0.05), and this increase was associated with smooth muscle proliferation, reduplication, and calcification of the elastica, but not with inflammatory cell infiltration.While the pathophysiologic significance of these changes is uncertain, the relation to duration of asthma, age, and smoking suggests a secondary response to chronic airway disease. |
Databáze: | OpenAIRE |
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