[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating
Autor: | Mark A. McKinlay, Guy D. Diana, C. Oglesby, Michael J. Otto, Vahan Akullian |
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Rok vydání: | 1985 |
Předmět: |
Time Factors
Picornavirus Chemical Phenomena Rhinovirus Stereochemistry Ether Oxazoline Virus Replication Virus chemistry.chemical_compound Mice Structure-Activity Relationship In vivo Drug Discovery Animals Oxazoles Alkyl chemistry.chemical_classification Picornaviridae Infections biology Dose-Response Relationship Drug Lethal dose Biological activity Isoxazoles biology.organism_classification Chemistry Poliovirus chemistry Molecular Medicine |
Zdroj: | Journal of medicinal chemistry. 28(12) |
ISSN: | 0022-2623 |
Popis: | A series of [[(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles has been synthesized and evaluated as antipicornavirus agents. The effect of alkyl groups in the 4- and 5-position of the oxazoline ring, as well as the alkyl chain length, on antiviral activity was examined. Compound 14 was evaluated in vivo and was found to significantly reduce mortality at an oral dose of 4 mg/kg in mice infected intracerebrally with poliovirus-2. Compound 14 was also effective in preventing paralysis when administered intraperitoneally to mice infected subcutaneously with a lethal dose of ECHO-9 virus. On the basis of the results of these studies, compound 14 is a strong candidate for clinical evaluation as a systemic agent for the treatment of picornavirus infections. |
Databáze: | OpenAIRE |
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