Gender effect on association between DRD2 polymorphism and substance dependence in a Spanish sample
| Autor: | M. Mercedes Perez-Rodriguez, Jerónimo Saiz-Ruiz, Enrique Baca-García, José Fernández-Piqueras, Jorge Lopez-Castroman, Concepción Vaquero-Lorenzo, Montserrat Diaz-Hernandez |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Genotype Substance-Related Disorders Single-nucleotide polymorphism Biology Toxicology Polymerase Chain Reaction Polymorphism Single Nucleotide law.invention law Molecular genetics medicine SNP Humans Pharmacology (medical) Allele Polymerase chain reaction Pharmacology Genetics Sex Characteristics Chi-Square Distribution Polymorphism Genetic Substance dependence Receptors Dopamine D2 Case-control study medicine.disease Psychiatry and Mental health Spain Case-Control Studies Female |
| Zdroj: | Drug and alcohol dependence. 101(3) |
| ISSN: | 1879-0046 |
| Popis: | Our aim was to examine a possible association between substance dependence and the TaqIA polymorphism of the D2 dopamine receptor (DRD2), a single nucleotide polymorphism (SNP) located at the 3' UTR region of the DRD2 gene. A case-control design stratified by gender was used to analyze the genotypes of this SNP in a sample of 125 substance-dependent patients according to DSM-IV and 203 blood donors recruited as controls in two general city hospitals in Madrid, Spain. Genomic DNA from peripheral blood samples was amplified through PCR to identify the variants of the SNP in the DRD2 gene. Analyses performed with Chi(2) tests revealed that the A1 allele (A1/A1 and A1/A2 genotypes) of the Taq 1A SNP of the DRD2 gene was significantly associated with substance dependence in males, but not in the whole sample. Male patients had significantly higher rates of the A1-containing genotypes than male controls. The finding of an association between substance dependence and the DRD2 gene TaqIA SNP only in males suggests the existence of gender-specific differences in the genetic underpinnings of substance dependence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect