A pharmacokinetic comparison of cephalexin and cefadroxil using HPLC assay procedures
| Autor: | Agber Ifan, Florence Kwok, John G. Pearson, Mark Rogge, Peter G. Welling, Diana Marrero, Arzu Selen, William A. Craig, Curtis A. Johnson |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Pharmacology Cephalexin Chromatography medicine.drug_class Chemistry Antibiotics Cefadroxil Pharmaceutical Science General Medicine Urine Hydrogen-Ion Concentration High-performance liquid chromatography Crossover study Kinetics Pharmacokinetics Oral administration medicine Humans Distribution (pharmacology) Pharmacology (medical) Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 6:147-157 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510060206 |
| Popis: | The pharmacokinetics of cephalexin and cefadroxil were compared following single 500 mg oral doses to 12 healthy male volunteers. Doses were administered after an overnight fast according to a crossover design. Plasma and urinary levels of both compounds were determined by HPLC procedures. Cephalexin was absorbed rapidly, achieving a mean peak plasma level of 17.5 micrograms ml-1 at 1 h, compared to 16 micrograms ml-1 at 1.8 h for cefadroxil. Elimination half-lives of cephalexin and cefadroxil were 0.7 and 1.1 h, respectively. The area under the cefadroxil plasma curve was significantly larger than that for cephalexin. However, after allowing for differences in elimination rate constants and assuming equal distribution volumes, plasma data indicated the compounds were equally well absorbed. Only 70 per cent of cefadroxil was recovered in urine compared to 87 per cent of cephalexin during the 12 h following drug administration. The therapeutic significance of the different pharmacokinetic characteristics of cephalexin and cefadroxil, if any, may be a function also of their pharmacologic activity and/or the sensitivity of the target organism. |
| Databáze: | OpenAIRE |
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