3H-delta 9-Tetrahydrocannabinol, 3H-cannabinol and 3H-cannabidiol: penetration and regional distribution in rat brain
| Autor: | Louis S. Harris, Billy R. Martin, William L. Dewey, Sydney O. Alozie |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Clinical Biochemistry Cannabinol Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Internal medicine mental disorders medicine Animals Cannabidiol Drug Interactions Dronabinol Biological Psychiatry Pharmacology Cannabinoids organic chemicals Significant difference Brain Penetration (firestop) Rat brain Rats Kinetics Endocrinology chemistry Hypothalamus Anesthesia Time course Δ9-tetrahydrocannabinol medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 12(2) |
| ISSN: | 0091-3057 |
| Popis: | 3H-delta 9-Tetrahydrocannabinol (3H-delta 9-THC), 3H-cannabidiol (3H-CBD) and 3H-cannabinol (3H-CBN) were administered (1 mg/kg) to male rats which were decapitated either 0.5, 1, 15, 30 or 90 min later. The plasma concentration was similar for all cannabinoids throughout the time course. After 5 min greater than 80% of the plasma radioactivity in each treatment was due to metabolites. Radioactivity rapidly entered brain after the administration of 3H-CBD, 3H-CBN, and 3H-delta 9-THC. The concentrations of unchanged 3H-CBD aand 3H-CBN in whole brain were higher than that of 3H-delta 9-THC 5 min after administration. Regional distribution of radioactivity in the brain after 5 min was similar for all three cannabinoids, the only significant difference being in hypothalamus. Coadministration of 3H-delta 9-THC with a five-fold excess of either CBD or delta 9-THC did not produce any significant alteration in the levels of radioactivity in brain or plasma 5 min after their injection. The difference in behavioral activity of delta 9-THC, CBD and CBN cannot be explained by penetrability or regional distribution in the brain. |
| Databáze: | OpenAIRE |
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