Correction: A 20-year audit of retinoblastoma treatment outcomes
| Autor: | Mehmed Uğur Işık, Emine Temel, Nurdan Tacyildiz, Ibadulla Mirzayev, Serdal Kenan Köse, Handan Dincaslan, Emel Ünal, Ahmet Kaan Gündüz, Funda Seher Özalp Ateş |
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| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Turkey genetic structures Retinal Neoplasms Treatment outcome MEDLINE Audit Eye Enucleation Article Eye cancer Text mining Antineoplastic Combined Chemotherapy Protocols medicine Humans Retrospective Studies Retinoblastoma business.industry Published Erratum Correction Infant medicine.disease eye diseases Retinal diseases Ophthalmology Treatment Outcome sense organs business |
| Zdroj: | Eye |
| ISSN: | 1476-5454 |
| Popis: | Objectives To evaluate the long-term treatment outcomes in intraocular retinoblastoma (RB) including the associated factors for eventual treatment with external beam radiotherapy (EBRT) and enucleation as well as to analyse the risk factors for metastasis and death in extraocular RB. Methods Retrospective analysis of 390 eyes from 256 (89.8%) intraocular RB and 29 (10.2%) extraocular RB cases diagnosed and treated between October 1998 and May 2018 at one of the largest tertiary care centers in Turkey. Results Of 351 intraocular RB eyes, 53.3% had group D/E disease at presentation. 75 (21.4%) of 351 eyes underwent primary enucleation. Of the remaining 276 eyes undergoing eye-conserving treatments, 201 (72.8%) were salvaged. Most of these eyes were treated using intravenous chemotherapy and/or focal treatments [transpupillary thermotherapy (TTT) and cryotherapy] initially. EBRT was eventually required in 48 (17.4%) eyes and secondary enucleation in 75 (27.2%) eyes. At mean follow-ups of 76.7 and 39.7 months for intraocular and extraocular RB cohorts, respectively, 180 (46.2%) eyes underwent primary/secondary enucleation and exenteration. Overall, 13 cases developed metastasis and 9 died. Two patients with trilateral RB also expired. Multivariable risk factors for enucleation were the presence of vitreous seeds (p |
| Databáze: | OpenAIRE |
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