5-HT1D and 5-HT1E/1F binding sites in depressed suicides: increased 5-HT1D binding in globus pallidus but not cortex
| Autor: | Cornelius Katona, Roger W. Horton, Sandra Lowther, M. R. Crompton |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male endocrine system Injury control Adolescent Accident prevention Poison control Globus Pallidus Cellular and Molecular Neuroscience Cortex (anatomy) Parietal Lobe Injury prevention medicine Humans Binding site Molecular Biology Aged Retrospective Studies Binding Sites Depression musculoskeletal neural and ocular physiology Putamen Middle Aged Antidepressive Agents nervous system diseases Frontal Lobe Psychiatry and Mental health Suicide Globus pallidus medicine.anatomical_structure nervous system Receptor Serotonin 5-HT1D Receptors Serotonin Female Psychology Neuroscience |
| Zdroj: | Molecular psychiatry. 2(4) |
| ISSN: | 1359-4184 |
| Popis: | 5-HT1D and 5-HT1E/1F receptor binding sites were measured in brain samples obtained at postmortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. In antidepressant-free suicides a significantly higher number of 5-HT1D receptors was found in globus pallidus. This was largely restricted to those suicides who died by violent means. This effect was not observed in antidepressant-treated suicides. No differences or trends in 5-HT1D binding were found in putamen, parietal or frontal cortex, in antidepressant-free or antidepressant-treated suicides. There were no differences in the number of 5-HT1E/1F receptors in any of the regions studied. |
| Databáze: | OpenAIRE |
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