Genomewide association of male reproductive traits in Aksaray Malakli dogs

Autor: Pürhan Barbaros Tuncer, Koray Tekin, Ongun Uysal, Umut Taşdemir, Muhammed Enes Inanç, Mustafa Yenal Akkurt, Burak Yilmaz, Kemal Tuna Olgac, Serhat Büyükleblebici, Beste Çil, Bengi Çinar Kul, Mehmet Kızılaslan
Přispěvatelé: Aksaray Teknik Bilimler Meslek Yüksekokulu, CINAR KUL, Bengi -- 0000-0002-8955-0097, INANC, MUHAMMED ENES -- 0000-0001-6954-6309, [Inanc, Muhammed Enes] Mehmet Akif Ersoy Univ, Dept Reprod & Artificial Inseminat, Fac Vet Med, Burdur, Turkey -- [Tekin, Koray -- Olgac, Kemal Tuna -- Yilmaz, Burak -- Cil, Beste -- Uysal, Ongun] Ankara Univ, Dept Reprod & Artificial Inseminat, Fac Vet Med, Ankara, Turkey -- [Akkurt, Mustafa Yenal -- Kul, Bengi Cinar] Ankara Univ, Dept Genet, Fac Vet Med, Ankara, Turkey -- [Kizilaslan, Mehmet] Int Ctr Livestock Res & Training, Ankara, Turkey -- [Tasdemir, Umut] Aksaray Univ, Tech Sci Vocat Sch, Aksaray, Turkey -- [Tuncer, Purhan Barbaros -- Buyukleblebici, Serhat] Mersin Univ, Tech Sci Vocat Sch, Mersin, Turkey
Rok vydání: 2018
Předmět:
Zdroj: Reproduction in domestic animals = Zuchthygiene. 53(6)
ISSN: 1439-0531
Popis: WOS: 000449849900037
PubMed: 30085374
Male reproductive parameters are often used for the functional examination and evaluation of predicted genetic values for future aspects. However, these traits are relatively reliable until the measurable effects are expressed on desired traits. Therefore, we aimed to associate the single nucleotide polymorphism (SNP) genotype of the investigated characteristics and reproductive loci. A total of 46 male dogs are divided into three age groups (I = 7 years, n = 8). The testis, scrotum and body weight, libido sexualis and ejaculation time for each fraction were monitored as functional traits, while the pH, fractional semen volume, motility, concentration, and abnormal and dead spermatozoa rate were recorded as spermatological traits. The Affymetrix Canine 127 K SNP genotyping array v2 (Affymetrix Inc., California, USA) was used for SNP genotyping. In the primary results, the scrotal circumference was found to be higher in group II compared to other groups (p < 0.05) and the lowest total abnormal spermatozoa rate was found in group I (p < 0.05). The normal spermatozoa rate was found to be significantly above the threshold in relation to the SNP in chromosome 17. In conclusion, this study represents an exciting first step towards SNP association with dog semen spermatological parameters. Future studies might be undertaken to evaluate this SNP region for gene-knockout and expression analysis and for fine mapping to validate and/or discover the exact position of the effect region.
Scientific and Technological Research Council of Turkey (TUBITAK) [114O636]
Scientific and Technological Research Council of Turkey (TUBITAK), Grant/Award Number: 114O636
Databáze: OpenAIRE
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