Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers
| Autor: | Mark N. Warden, Susan Searles Nielsen, Joel S. Perlmutter, Stephen M. Moerlein, Jason Lenox-Krug, Susan R. Criswell, Wendy W. Dlamini, Lianne Sheppard, Harvey Checkoway, Brad A. Racette |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Neurotoxicology
0301 basic medicine medicine.medical_specialty Substantia nigra Nucleus accumbens Toxicology 03 medical and health sciences Benperidol 0302 clinical medicine Dopamine Internal medicine Dopamine receptor D2 medicine Humans Manganese Principal Component Analysis business.industry Putamen Dopaminergic Brain Corpus Striatum 030104 developmental biology Endocrinology Dopamine receptor Positron-Emission Tomography business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Toxicol Sci |
| ISSN: | 1096-0929 1096-6080 |
| Popis: | The relationships between the neurotoxicant manganese (Mn), dopaminergic pathology, and parkinsonism remain unclear. Therefore, we used [11C](N-methyl)benperidol (NMB) positron emission tomography to investigate the associations between Mn exposure, striatal and extrastriatal D2 dopamine receptors (D2R), and motor function in 54 workers with a range of Mn exposure. Cumulative Mn exposure was estimated from work histories, and all workers were examined by a movement specialist and completed a Grooved Pegboard test (GPT). NMB D2R nondisplaceable binding potentials (BPND) were calculated for brain regions of interest. We identified 2 principal components (PCs) in a PC analysis which explained 66.8% of the regional NMB BPND variance (PC1 = 55.4%; PC2 = 11.4%). PC1 was positively correlated with NMB binding in all regions and inversely correlated with age. PC2 was driven by NMB binding in 7 brain regions (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|