Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B

Autor:	Ali Sardarian, Madeleine Helliwell, Laura L. Etchells, Roger C. Whitehead, Neil M. Kershaw
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Drug Discovery Organic chemistry General Medicine Biochemistry Pyrrolidine
Zdroj:	Tetrahedron. 62:10914-10927
ISSN:	0040-4020
Popis:	The pyrrolidine natural products, plakoridines A and B, as well as an array of unnatural analogues, have been prepared using a five-step synthetic sequence modelled on a biogenetic theory. The key transformation involves a ‘Mannich/Michael/internal-redox’ cascade, which proceeds in yields of 31–63%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e4b5fec73434fb61f71d22dd726914 https://doi.org/10.1016/j.tet.2006.08.075 Zobrazit plný text záznamu Full Text from ScienceDirect