Plasma vitamins B2, B6, B12, and related genetic variants as predictors of colorectal cancer risk
| Autor: | Simone J. P. M. Eussen, Øivind Midttun, Kim Overvad, Elio Riboli, Tobias Pischon, Ole Thorlacius-Ussing, Paolo Vineis, Rudolf Kaaks, Laudina Rodríguez, Domenico Palli, Bethany VanGuelpen, Mazda Jenab, Per Magne Ueland, Ulrika Ericson, Cornelia Weikert, Åse Fredriksen, Anne Tjønneland, Carmen Enid Martínez, Petra H.M. Peeters, Paolo Boffetta, Klaus Meyer, Carmen Navarro, H. Bas Bueno-de-Mesquita, Jonas Manjer, Valeria Pala, Françoise Clavel-Chapelon, Teresa Norat, Sophie Morois, Fränzel J.B. Van Duijnhoven, Anja Olsen, Rosario Tumino, Kay-Tee Khaw, Steinar Hustad, Jakob Linseisen, Michael Katsoulis, Richard Palmqvist, Stein Emil Vollset, Sheila Bingham, Antonia Trichopoulou, Guri Skeie, Miren Dorronsoro, Demosthenes Zilis, Nadia Slimani, Eva Ardanaz, Salvatore Panico, Xavier Muñoz, Marie-Christine Boutron-Ruault |
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| Přispěvatelé: | Eussen, Sj, Vollset, Se, Hustad, S, Midttun, Ø, Meyer, K, Fredriksen, A, Ueland, Pm, Jenab, M, Slimani, N, Boffetta, P, Overvad, K, Thorlacius Ussing, O, Tjønneland, A, Olsen, A, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Weikert, C, Pischon, T, Linseisen, J, Kaaks, R, Trichopoulou, A, Zilis, D, Katsoulis, M, Palli, D, Pala, V, Vineis, P, Tumino, R, Panico, Salvatore, Peeters, Ph, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Skeie, G, Muñoz, X, Martínez, C, Dorronsoro, M, Ardanaz, E, Navarro, C, Rodríguez, L, Vanguelpen, B, Palmqvist, R, Manjer, J, Ericson, U, Bingham, S, Khaw, Kt, Norat, T, Riboli, E., Eussen, S.J.P.M., Vollset, S.E., Hustad, S., Midttun, Ø., Meyer, K., Fredriksen, Å., Ueland, P.M., Jenab, M., Slimani, N., Boffetta, P., Overvad, K., Thorlacius-Ussing, O., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Weikert, C., Pischon, T., Linseisen, J., Kaaks, R., Trichopoulou, A., Zilis, D., Katsoulis, M., Palli, D., Pala, V., Vineis, P., Tumino, R., Panico, S., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Van Duijnhoven, F.J.B., Skeie, G., Muñoz, X., Martínez, C., Dorronsoro, M., Ardanaz, E., Navarro, C., Rodríguez, L., VanGuelpen, B., Palmqvist, R., Manjer, J., Ericson, U., Bingham, S., Khaw, K.-T., Norat, T. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Male medicine.medical_specialty Epidemiology Colorectal cancer Riboflavin Polymorphism Single Nucleotide Article Cohort Studies Folic Acid Risk Factors Internal medicine Genotype medicine Humans Vitamin B12 ONE-CARBON METABOLISM METHIONINE SYNTHASE GENE METHYLENETETRAHYDROFOLATE REDUCTASE FOLATE METABOLISM MASS-SPECTROMETRY HOMOCYSTEINE METABOLISM DNA METHYLATION DIETARY-INTAKE RAT-LIVER POLYMORPHISMS B12 biology colorectal cancer risk business.industry Case-control study Cancer Middle Aged medicine.disease Vitamin B 6 B vitamins Vitamin B 12 Endocrinology Methylenetetrahydrofolate reductase Case-Control Studies biology.protein B6 Female B2 business Colorectal Neoplasms Cohort study |
| Zdroj: | Eussen, S J, Vollset, S E, Hustad, S, Midttun, O, Meyer, K, Fredriksen, A, Ueland, P M, Jenab, M, Slimani, N, Boffetta, P, Overvad, K, Thorlacius-Ussing, O, Tjonneland, A M, Olsen, A, Clavel-Chapelon, F, Boutron-Ruault, M-C, Morois, S, Weikert, C, Pishon, T, Linseisen, J, Kaaks, R, Trichopoulou, A, Zilis, D, Katsoulis, M, Palli, D, Pala, V, Vineis, P P, Tumino, R, Panico, S, Peeters, P H M, Bueno-de-Mesquita, H B, van Duijnhoven, F, Skeie, G, Muñoz, X, Martínez-García, C, Dorronsoro, M, Ardanaz, E, Navarro, C, Rodriguez, L, Van Guelpen, B, Palmqvist, R, Manjer, J, Ericson, U C, Bingham, S A, Khaw, K-T, Norat, T, Riboli, E & Thorlacius-Ussing, O 2010, ' Plasma vitamins B2, B6, B12, and related genetic variants as predictors of colorectal cancer risk ', Cancer Epidemiology, Biomarkers & Prevention, vol. 19, no. 10, pp. 2549-2561 . https://doi.org/10.1158/1055-9965.EPI-10-0407 Cancer Epidemiol. Biomarkers Prev. 19, 2549-2561 (2010) |
| Popis: | Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat. Results: The relative risks comparing highest to lowest quintile were 0.71 [95% confidence interval (95% CI), 0.56-0.91; Ptrend = 0.02] for vitamin B2, 0.68 (95% CI, 0.53-0.87; Ptrend Conclusions: Higher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. Impact: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2549–61. ©2010 AACR. |
| Databáze: | OpenAIRE |
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