Asymmetric c-fos expression in the ventral orbital cortex is associated with impaired reversal learning in a right-sided neuropathy
| Autor: | Nuno Ribeiro-Costa, Armando Almeida, Hugo Leite-Almeida, Nuno Sousa, João José Cerqueira, Helena Anjos-Martins, Marco Rafael Guimarães |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pain Threshold Short Report Prefrontal Cortex Cell Count Reversal Learning Attentional set-shifting task Neuropathic pain Prefrontal cortex Lateralization of brain function Functional Laterality Statistics Nonparametric Cellular and Molecular Neuroscience Discrimination Psychological Reversal learning Cortex (anatomy) Physical Stimulation Threshold of pain medicine Animals Attention Rats Wistar Pain Measurement Neurons Science & Technology Lateralization C-fos Learning Disabilities Chronic pain Nerve injury medicine.disease Rats Disease Models Animal Anesthesiology and Pain Medicine medicine.anatomical_structure Laterality Molecular Medicine Neuralgia medicine.symptom Psychology Neuroscience Proto-Oncogene Proteins c-fos |
| Zdroj: | Molecular Pain Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1744-8069 |
| Popis: | BACKGROUND: Recently we showed that unilateral peripheral neuropathic lesions impacted differentially on rat's emotional/cognitive behavior depending on its left/right location; importantly, this observation recapitulates clinical reports. The prefrontal cortex (PFC), a brain region morphofunctionally affected in chronic pain conditions, is involved in the modulation of both emotion and executive function and displays functional lateralization. To test whether the PFC is involved in the lateralization bias associated with left/right pain, c-fos expression in medial and orbital areas was analyzed in rats with an unilateral spared nerve injury neuropathy installed in the left or in the right side after performing an attentional set-shifting, a strongly PFC-dependent task. RESULTS: SNI-R animals required more trials to successfully terminate the reversal steps of the attentional set-shifting task. A generalized increase of c-fos density in medial and orbital PFC (mPFC/OFC), irrespectively of the hemisphere, was observed in both SNI-L and SNI-R. However, individual laterality indexes revealed that contrary to controls and SNI-L, SNI-R animals presented a leftward shift in c-fos density in the ventral OFC (VO). None of these effects were observed in the neighboring primary motor area. CONCLUSIONS: Our results demonstrate that chronic neuropathic pain is associated with a bilateral mPFC and OFC hyperactivation. We hypothesize that the impaired performance of SNI-R animals is associated with a left/right activity inversion in the VO, whose functional integrity is critical for reversal learning. This work was granted by the Portuguese Science Foundation (FCT) project PTDC/SAU-NEU/108557/2008 and grant SFRH/BPD/80118/2011. |
| Databáze: | OpenAIRE |
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