The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice
| Autor: | Chantal Mathis, John C. Lehmann, Arielle Ungerer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Ratón Amnesia Pharmacology Receptors N-Methyl-D-Aspartate Mice Piperidines Memory medicine Animals Memory disorder Protein Kinase C Protein kinase C chemistry.chemical_classification Dose-Response Relationship Drug biology medicine.disease Enzyme chemistry Enzyme inhibitor biology.protein NMDA receptor Memory consolidation medicine.symptom Neuroscience Injections Intraperitoneal |
| Zdroj: | European Journal of Pharmacology. 220:107-110 |
| ISSN: | 0014-2999 |
| Popis: | We studied the effects of a selective inhibitor of protein kinase C (PKC), 2,6-diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl]methyl)hexamide (NPC 15437), on acquisition and memory retention of a Y-maze avoidance task in mice. Post-training administration of NPC 15437 (0.1-10 mg/kg i.p.) induced a dose-dependent deficit in retention of the temporal but not the spatial component of the task. This selective amnesia does not reflect state dependence and NPC 15437 (1 mg/kg) had no effect on acquisition and memory retrieval. Our results suggest that this new PKC inhibitor interferes with mechanisms underlying memory consolidation. This is in agreement with recent findings suggesting that PKC is involved in memory processes. |
| Databáze: | OpenAIRE |
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