Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome
| Autor: | Wayne F. Anderson, Jane C. Naviaux, Eric M Gordon, Robert K. Naviaux, A. Taylor Bright, Neil Nathan, Kefeng Li, William A. Alaynick, Lin Wang, Asha Baxter |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
030110 physiology
0301 basic medicine Multidisciplinary Fatigue Syndrome Chronic business.industry Disease medicine.disease Biochemical phenotype 03 medical and health sciences 0302 clinical medicine Metabolomics Sphingolipid metabolism Immunology Chronic fatigue syndrome medicine Humans 030212 general & internal medicine Letters business Neuroscience Sickness behavior Fatigue |
| Popis: | We thank Vogt et al. for their comments (1). We respond to their three points in order. First, we are aware of the need to extend future metabolomics studies to include other disease groups. We stated this fact in the discussion of ref. 2 and are validating the results in independent cohorts. The detailed biochemical phenotype or signature that we found provides a first glimpse at a previously hidden biology. For example, disturbances in sphingolipid metabolism have important implications for immunobiology and neuroendocrine regulation relevant to myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (3). Sphingolipids are important mediators of the cell danger response (CDR) (4), and the CDR is an important regulator of the behavioral and functional changes produced by infection, and associated with sickness behavior … [↵][1]1To whom correspondence should be addressed. Email: rnaviaux{at}ucsd.edu. [1]: #xref-corresp-1-1 |
| Databáze: | OpenAIRE |
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