Impact of Additional Chromosomal Aberrations on the Disease Progression of Chronic Myelogenous Leukemia
| Autor: | Ramachandran Krishna Chandran, Narayanan Geetha, Kunnathur Murugesan Sakthivel, Raveendran Suresh Kumar, Kumarapillai Mohanan Nair Jagathnath Krishna, Hariharan Sreedharan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Genome instability Cancer Research medicine.medical_specialty variant Ph translocation Philadelphia chromosome lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine chronic myeloid leukemia Internal medicine hemic and lymphatic diseases medicine Philadelphia Chromosome Original Research ABL GTG-banding business.industry Incidence (epidemiology) Spectral Karyotyping breakpoint cluster region Myeloid leukemia Karyotype lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease blast crisis 030104 developmental biology 030220 oncology & carcinogenesis fluorescent in situ hybridization additional chromosomal aberrations business Chronic myelogenous leukemia |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 9 (2019) |
| ISSN: | 2234-943X |
| Popis: | The emergence of additional chromosomal abnormalities (ACAs) in Philadelphia chromosome/BCR-ABL1 positive chronic myeloid leukemia (CML), is considered to be a feature of disease evolution. However, their frequency of incidence, impact on prognosis and treatment response effect in CML is not conclusive. In the present study, we performed a chromosome analysis of 489 patients in different clinical stages of CML, using conventional GTG-banding, Fluorescent in situ Hybridization and Spectral Karyotyping. Among the de novo CP cases, ACAs were observed in 30 patients (10.20%) with lowest incidence, followed by IM resistant CP (16.66%) whereas in AP and BC, the occurrence of ACAs were higher, and was about 40.63 and 50.98%, respectively. The frequency of occurrence of ACAs were compared between the study groups and it was found that the incidence of ACAs was higher in BC compared to de novo and IM resistant CP cases. Likewise, it was higher in AP patients when compared between de novo and IM resistant CP cases, mirroring the fact of cytogenetic evolution with disease progression in CML. In addition, we observed 10 novel and 10 rare chromosomal aberrations among the study subjects. This study pinpoints the fact that the genome of advanced phase patients was highly unstable, and this environment of genomic instability is responsible for the high occurrence of ACAs. Treatment response analysis revealed that compared to initial phases, ACAs were associated with an adverse prognostic effect during the progressive stages of CML. This study further portrayed the cytogenetic mechanism of disease evolution in CML. |
| Databáze: | OpenAIRE |
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