Radiation recall dermatitis after treatment of stage IV breast cancer with nivolumab: a case report
| Autor: | Abhay Gokhale, Shilpa Padia, Bridget O'Brien, Malolan Rajagopalan, Jeanna Knoble, Cole Billena |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Immunology Breast Neoplasms Modified Radical Mastectomy 030207 dermatology & venereal diseases 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Breast cancer medicine Humans Immunology and Allergy Adverse effect Aged Chemotherapy business.industry Carcinoma Ductal Breast medicine.disease Rash Dermatology Radiation therapy Nivolumab Radiation Recall Dermatitis Oncology 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Radiodermatitis medicine.symptom business |
| Zdroj: | Immunotherapy. 12:123-130 |
| ISSN: | 1750-7448 1750-743X |
| Popis: | Radiation recall dermatitis (RRD) is an uncommon dermatologic reaction provoked notably by chemotherapy in an area of skin irradiated weeks to years prior. We report a case of RRD with nivolumab in a woman with breast cancer. The patient was diagnosed with invasive ductal carcinoma of the left breast with an isolated spinal metastasis approached in an oligometastatic fashion with neoadjuvant chemotherapy, modified radical mastectomy and adjuvant radiotherapy. Unfortunately, after progression of bony metastases treated with radiotherapy, the patient received nivolumab and subsequently developed a rash corresponding to the adjuvant radiation field. This case highlights the unpredictable nature and characteristic rash of RRD. It is an important differential diagnosis for multidisciplinary teams who also see chemotherapy-induced dermatitis and immune-related adverse events. |
| Databáze: | OpenAIRE |
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