LFA-1 in T cell priming, differentiation, and effector functions
| Autor: | Andrew P. Cope, Claudia Kemper, Audrey Gérard, Robert Köchl, Ronen Alon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
T cell
Immunology Integrin Cell Priming (immunology) Antigen-Presenting Cells chemical and pharmacologic phenomena hemic and immune systems Cell Differentiation Biology Th1 Cells Intercellular Adhesion Molecule-1 Immunological Synapses Lymphocyte Function-Associated Antigen-1 Cell biology Mechanobiology medicine.anatomical_structure biology.protein medicine Immunology and Allergy Animals Cytoskeleton Intracellular |
| Popis: | The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells. However, it is increasingly evident that LFA-1 plays additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or antigen-presenting cells. These include roles in homotypic T cell: T cell communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we summarize briefly current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation. |
| Databáze: | OpenAIRE |
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