BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
| Autor: | Andrew M. Anisfeld, Peter A. Edwards, Heidi Rachelle Kast |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Tangier disease sitosterolemia QD415-436 Biology digestive system Biochemistry chemistry.chemical_compound Endocrinology Internal medicine medicine Liver X receptor Receptor bile acids Pregnane X receptor Bile acid Fatty acid metabolism Cholesterol Cell Biology lipoproteins ABC transporters chemistry Nuclear receptor oxysterols lipids (amino acids peptides and proteins) Drug metabolism |
| Zdroj: | Journal of Lipid Research, Vol 43, Iss 1, Pp 2-12 (2002) |
| ISSN: | 0022-2275 |
| Popis: | During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRα, NR1H3, and LXRβ, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear receptors play in controlling cholesterol, bile acid, lipoprotein and drug metabolism. The current interest in these nuclear receptors is high, in part, because they appear to be promising therapeutic targets for new drugs that have the potential to control lipid homeostasis. In this review we emphasize i) the role of LXR in controlling many aspects of cholesterol and fatty acid metabolism, ii) the expanded role of FXR in regulating genes that control not only bile acid metabolism but also lipoprotein metabolism, and iii) the regulation of bile acid transport/metabolism in response to bile acid-activated PXR. — Edwards, P. A., H. R. Kast, and A. M. Anisfeld. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 2002. 43: 2–12. |
| Databáze: | OpenAIRE |
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