Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells
| Autor: | Ana Sánchez, Mercedes Alberca, Javier García-Sancho, Marina Huguet, Juan Jose Fuertes, Aurelio Vega, Robert Soler, Verónica García, Francisco Del Canto, Anna Munar, Lluis Orozco, Miguel Ángel Martín-Ferrero |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Ministerio de Sanidad y Política Social (España), Instituto de Salud Carlos III, Junta de Castilla y León |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Cartilage Articular Male Oncology medicine.medical_specialty Time Factors Stromal cell Knee Joint Osteoarthritis Mesenchymal Stem Cell Transplantation Injections Intra-Articular law.invention Lesion Disability Evaluation Randomized controlled trial law Internal medicine medicine Humans Transplantation Homologous Aged Bone Marrow Transplantation Pain Measurement Transplantation business.industry Cartilage Mesenchymal stem cell Middle Aged Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Treatment Outcome medicine.anatomical_structure Spain Joint pain Quality of Life Female medicine.symptom business |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0000000000000678 |
| Popis: | [Background]: Osteoarthritis is themost prevalent joint disease and a common cause of joint pain, functional loss, and disability. Conventional treatments demonstrate only modest clinical benefits without lesion reversal. Autologous mesenchymal stromal cell (MSC) treatments have shown feasibility, safety, and strong indications for clinical efficacy. We performed a randomized, active control trial to assess the feasibility and safety of treating osteoarthritis with allogeneic MSCs, and we obtain information regarding the efficacy of this treatment. [Methods]: We randomized 30 patients with chronic knee pain unresponsive to conservative treatments and showing radiological evidence of osteoarthritis into 2 groups of 15 patients. The test group was treated with allogeneic bone marrow MSCs by intra-articular injection of 40 × 106 cells. The control group received intra-articular hyaluronic acid (60 mg, single dose). Clinical outcomes were followed for 1 year and included evaluations of pain, disability, and quality of life. Articular cartilage quality was assessed by quantitative magnetic resonance imaging T2 mapping. [Results]: Feasibility and safety were confirmed and indications of clinical efficacy were identified. The MSC-treated patients displayed significant improvement in algofunctional indices versus the active controls treated with hyaluronic acid. Quantification of cartilage quality by T2 relaxation measurements showed a significant decrease in poor cartilage areas, with cartilage quality improvements inMSC-treated patients. [Conclusions]: Allogeneic MSC therapy may be a valid alternative for the treatment of chronic knee osteoarthritis that is more logistically convenient than autologous MSC treatment. The intervention is simple, does not require surgery, provides pain relief, and significantly improves cartilage quality. Financial support was provided by the Program for Support of Independent Clinical Research of the Spanish Ministerio de Sanidad (EC11-309), Red de Terapia Celular (RD06/0010/0000 and RD12/0019/0036) of the Instituto de Salud Carlos III, Ministerio de Economia y Competitividad, and the Centro en Red de Medicina Regenerativa de Castilla y León. |
| Databáze: | OpenAIRE |
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