| Autor: |
Masahide Takahashi, Atsushi Enomoto, Yoshiki Hirooka, Mitsuhiro Fujishiro, Teppei Shimamura, Daniel Worthley, Susan L. Woods, Tongtong Wang, Junpei Yamaguchi, Suguru Yamada, Tsutomu Fujii, Tomoe Kobayashi, Makoto Matsuyama, Takaki Miyata, Arata Nagasaka, Hisashi Haga, Matthew W. Conklin, Suzanne M. Ponik, Seiichiro Ishihara, Liang Weng, Kenju Ando, Yukihiro Shiraki, Shinji Mii, Kaori Ushida, Nobutoshi Esaki, Akitoshi Hara, Atsushi Masamune, Naoya Asai, Tadashi Iida, Hiroki Kobayashi, Yasuyuki Mizutani |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22422468 |
| Popis: |
Supplementary data contains additional methods and figures. The figures contain the following information: Supplementary Figure 1 extends Figure 1 providing evidence that Meflin is expressed in BM MSCs and PSCs in mice. Supplementary Figure 2 supports Figure 1 showing the development of the Meflin-ZDC mice. Supplementary Figure 3-5 extend Figure 1 providing additional evidence that Meflin is specifically expressed in PSCs and CAFs and its expression is regulated by calcipotriol. Supplementary Figure 6-9 support Figure 2 showing the detection of Meflin expression at the protein and mRNA levels in human and mouse PDAC. Supplementary Figure 10 and 11 support Figure 2 showing the data of single-cell RNA sequencing of CAFs isolated from PDAC and breast cancer mouse models. Supplementary Figure 12 supports Figure 3 showing the effects of Meflin depletion on the global gene expression profiles in mouse MSCs. Supplementary Figure 13 supports Figure 3 showing the analysis of tumors developed in WT and Meflin-KO KPC mice. Supplementary Figure 14 supports Figure 6 showing the development of the Meflin-CreERT2 mice. Supplementary Figure 15 and 16 support Figure 7 showing the effect of exogenous Meflin expression on MSC gene expression and the growth of xenograft tumors. Supplementary Figure 17 support Figure 7 showing the role of Meflin in collagen remodeling in mouse and human PDAC. Supplementary Table 1 and 2 show the description of the cohort of PDAC patients included in the analysis and univariate and multivariate Cox regression analysis of human PDAC cases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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