The cytoneme connection: direct long-distance signal transfer during development
| Autor: | Ana-Citlali Gradilla, Isabel Guerrero, Laura González-Méndez |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Cellular differentiation Connection (vector bundle) Cell Membrane Synapsis Cell Communication Biology Signal Synapse 03 medical and health sciences Chromosome Pairing 0302 clinical medicine Animals Humans Pseudopodia Molecular Biology Filopodia Neuroscience 030217 neurology & neurosurgery Function (biology) 030304 developmental biology Developmental Biology Cytoneme Signal Transduction |
| Zdroj: | Development (Cambridge, England). 146(9) |
| ISSN: | 1477-9129 |
| Popis: | During development, specialized cells produce signals that distribute among receiving cells to induce a variety of cellular behaviors and organize tissues. Recent studies have highlighted cytonemes, a type of specialized signaling filopodia that carry ligands and/or receptor complexes, as having a role in signal dispersion. In this Primer, we discuss how the dynamic regulation of cytonemes facilitates signal transfer in complex environments. We assess recent evidence for the mechanisms for cytoneme formation, function and regulation, and postulate that contact between cytoneme membranes promotes signal transfer as a new type of synapse (morphogenetic synapsis). Finally, we reflect on the fundamental unanswered questions related to understanding cytoneme biology. |
| Databáze: | OpenAIRE |
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