Increased levels of lipocalin 2 in palmoplantar pustular psoriasis
| Autor: | Jörg Wenzel, Rotraut Mössner, Sandra Phillipp, Yvonne Frambach, Dagmar Wilsmann-Theis, E. Witte‐Händel, Kerstin Wolk, Arnd Jacobi, Robert Sabat |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Keratinocytes Male 0301 basic medicine Neutrophils Interleukin-1beta Primary Cell Culture Dermatology Lipocalin Severity of Illness Index Biochemistry Interleukin 22 Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Lipocalin-2 Risk Factors Psoriasis medicine Humans Resistin Molecular Biology Aged Epidermis (botany) business.industry Middle Aged Atherosclerosis medicine.disease Immunohistochemistry Up-Regulation 3. Good health 030104 developmental biology Epidermal Cells Concomitant Immunology Leukocytes Mononuclear Quality of Life Biomarker (medicine) Female Epidermis business Biomarkers |
| Zdroj: | Journal of Dermatological Science. 90:68-74 |
| ISSN: | 0923-1811 |
| DOI: | 10.1016/j.jdermsci.2017.12.018 |
| Popis: | Background Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles. Objective To identify and characterize pathogenetic players in PPP. Methods Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Healthy participants served as controls. Analysis of patient samples and cultured primary skin cells was performed by ELISA, qRT-PCR, and immunohistochemistry. Results Upon screening of blood mediators in PPP patients, lipocalin 2 (LCN2) emerged as being significantly upregulated compared to healthy participants. LCN2 blood levels were independent of age, sex, or concomitant psoriasis vulgaris. Keratinocytes in PPP skin lesions were important LCN2 producers. In vitro, LCN2 production of these cells was upregulated by IL-1β and further enhanced by IL-17 and TNF-α, while IL-22 had no effect. Accordingly, a positive relationship between blood IL-1β and LCN2 levels was evident in PPP. LCN2 blood levels also showed a positive correlation with PPP pustule score, Dermatology Quality of Life Index and blood levels of the pro-atherogenic molecule resistin. Conclusions In PPP, increased blood levels of LCN2 indicate an important activity of IL-1β in the epidermis, may contribute to skin neutrophil infiltration, and may point to an increased pro- atherosclerosis risk. |
| Databáze: | OpenAIRE |
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