Latent Class Growth Analysis of Gout Flare Trajectories: A Three‐Year Prospective Cohort Study in Primary Care
Autor: | John Belcher, Sara Muller, Edward Roddy, Christian D Mallen, Elaine Nicholls, Lorraine Watson |
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Rok vydání: | 2020 |
Předmět: |
Male
musculoskeletal diseases Pediatrics medicine.medical_specialty Gout Allopurinol Immunology Symptom Flare Up Class (philosophy) Primary care Gout Suppressants law.invention 03 medical and health sciences 0302 clinical medicine Rheumatology law Humans Immunology and Allergy Medicine 030212 general & internal medicine Prospective cohort study Aged 030203 arthritis & rheumatology Primary Health Care business.industry Middle Aged medicine.disease R1 Uric Acid Serum urate Disease Progression Female business RA medicine.drug Flare |
Zdroj: | Arthritis & Rheumatology. 72:1928-1935 |
ISSN: | 2326-5205 2326-5191 |
Popis: | Objective\ud To investigate the existence of distinct classes of gout flare trajectories and compare their gout‐specific, comorbid, and sociodemographic characteristics.\ud \ud Methods\ud In a prospective cohort study, adults with gout who were registered with 20 general practices self‐reported the number of gout flares experienced at baseline and after 6, 12, 24, and 36 months via postal questionnaires. Latent class growth analysis (LCGA) was used to identify distinct gout flare trajectory classes. Statistical criteria and clinical interpretability were used to decide the optimal number of classes. Baseline comorbidities, medications, and sociodemographic and gout‐specific characteristics of members of each class were described.\ud \ud Results\ud A total of 1,164 participants (mean ± SD age 65.6 ± 12.5 years; 972 [84%] male) were included. Six latent gout flare trajectory classes were identified: “frequent and persistent” (n = 95), “gradually worsening” (n = 276), “frequent then improving” (n = 14), “moderately frequent” (n = 287), “moderately frequent then improving” (n = 143), and “infrequent” (n = 349). The “frequent and persistent” trajectory had the most class members classified as obese and, along with the “gradually worsening” class, the highest proportion who were socioeconomically deprived. The “frequent and persistent,” “gradually worsening,” and ”frequent then improving” classes had the highest proportions of class members with an estimated glomerular filtration rate |
Databáze: | OpenAIRE |
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