RAGE Mediates a Novel Proinflammatory Axis
| Autor: | Steven Drury, Marion A. Hofmann, Timothy Slattery, Angelika Bierhaus, John McClary, Dale L. Beach, John Morser, Ann Marie Schmidt, Mariko Nagashima, Neeraja Kambham, Peter P. Nawroth, Akihiko Taguchi, Caifeng Fu, Markus F. Neurath, Wu Qu, David M. Stern, Cecilia Avila, Yan Lu |
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| Rok vydání: | 1999 |
| Předmět: |
endocrine system diseases
biology Biochemistry Genetics and Molecular Biology(all) nutritional and metabolic diseases Inflammation S100A12 Protein General Biochemistry Genetics and Molecular Biology Cell biology RAGE (receptor) Proinflammatory cytokine Cell surface receptor Immunology cardiovascular system biology.protein medicine Calgranulin cardiovascular diseases medicine.symptom Signal transduction Receptor human activities |
| Zdroj: | Cell. 97(7):889-901 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/s0092-8674(00)80801-6 |
| Popis: | S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathways and expression of inflammatory gene mediators. These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury. |
| Databáze: | OpenAIRE |
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