N,N'-Substituted Selenoureas as Polyfunctional Antioxidants
| Autor: | Igor V. Serkov, T. P. Serkova, Elena F. Shevtsova, L. G. Dubova, Alexey N. Proshin, O. M. Redkozubova, Margarita E. Neganova |
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| Rok vydání: | 2014 |
| Předmět: |
inorganic chemicals
0301 basic medicine Antioxidant medicine.medical_treatment Selenourea chemistry.chemical_element Alkylation 01 natural sciences Medicinal chemistry Oxygen Ferric Compounds General Biochemistry Genetics and Molecular Biology Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Organoselenium Compounds medicine Animals Urea 010405 organic chemistry General Medicine Rat brain 0104 chemical sciences Rats 030104 developmental biology chemistry Biochemistry Intramolecular force Lipid Peroxidation Reactive Oxygen Species Oxidation-Reduction Selenium |
| Zdroj: | Bulletin of experimental biology and medicine. 160(3) |
| ISSN: | 1573-8221 |
| Popis: | Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N'-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N'-substituted selenourea analogs. |
| Databáze: | OpenAIRE |
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