The topical effects of Wy-41,195 [2-cyano-3-(methylamino)phenylamino] oxoacetic acid, sodium salt and disodium cromoglycate in the rat passive eyelid anaphylaxis
| Autor: | Richard P. Carlson, Alan J. Lewis, Lynn O’Neill-Davis |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Immunosuppression Therapy
Oxamic Acid Passive anaphylaxis business.industry Administration Topical Immunology Passive Cutaneous Anaphylaxis Eyelids Rats Inbred Strains General Medicine medicine.disease Sodium salt Rats medicine.anatomical_structure Disodium cromoglycate Cromolyn Sodium Immunology and Allergy Medicine Animals Eyelid Amino Acids business Anaphylaxis |
| Zdroj: | International archives of allergy and applied immunology. 76(1) |
| ISSN: | 0020-5915 |
| Popis: | Wy-41,195 demonstrated significant inhibitory effects (54–60%) when administerd topically at 0.25–2% concentrations in a rat passive eyelid anaphylaxis assay. In contrast, topically applied disodium cromoglycate (DSCG) showed non significant inhibition at these concentrations. The potency of Wy-41,195 was more than 8 times greater than DSCG, and this compound may be an effective topical agent in man in preventing allergic and associated conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|