L-DOPA oxidation products prevent H2O2-induced oxidative damage to cellular DNA
| Autor: | John A. Buswell, Yu-ling Shi, Iris F.F. Benzie |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Antioxidant
DNA damage Tyrosinase medicine.medical_treatment Cell medicine.disease_cause General Biochemistry Genetics and Molecular Biology Levodopa Oxidative damage Tumor Cells Cultured medicine Humans General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Gel electrophoresis Reactive oxygen species Hydrogen Peroxide General Medicine Oxidants Oxidative Stress medicine.anatomical_structure chemistry Biochemistry Oxidation-Reduction Oxidative stress DNA Damage |
| Zdroj: | Life Sciences. 71:3047-3057 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(02)02172-0 |
| Popis: | Using the single-cell gel electrophoresis ("Comet") assay, we show that tyrosinase-generated L-DOPA oxidation products prevent H2O2-induced oxidative DNA damage in cultured tissue cells. We propose that these oxidation products trigger cellular processes that up-regulate the overall antioxidant status of the cell, and could be incorporated into treatments of pathological conditions associated with elevated oxidative DNA damage and other manifestations of increased oxidative stress. |
| Databáze: | OpenAIRE |
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