Solitary Primary Cutaneous CD30+ Large Cell Lymphoma of Natural Killer Cell Phenotype Bearing the t(2;5)(p23;q35) Translocation and Presenting in a Child
| Autor: | Zaim Mt, Jennifer W. Gould, Anita C. Gilliam, Gary S. Wood, Jeffrey Goldstein, Debra Mikkola, R Eppes |
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| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms CD30 Ki-1 Antigen Chromosomal translocation Dermatology Biology Polymerase Chain Reaction Translocation Genetic Pathology and Forensic Medicine Natural killer cell Immunoenzyme Techniques Antigens Neoplasm immune system diseases hemic and lymphatic diseases medicine Humans integumentary system Large cell Large-cell lymphoma DNA Neoplasm General Medicine medicine.disease Phenotype Lymphoma Killer Cells Natural medicine.anatomical_structure Child Preschool Chromosomes Human Pair 2 Chromosomes Human Pair 5 Lymphoma Large-Cell Anaplastic Immunohistochemistry Female |
| Zdroj: | The American Journal of Dermatopathology. 22:422-428 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/00000372-200010000-00007 |
| Popis: | Primary cutaneous CD30+ large cell lymphoma is an unusual tumor most commonly seen in adults. Most of these lymphomas are of T-cell origin and carry a good prognosis. We present the case of a 4-year-old girl with stage IEA CD30+ large cell lymphoma with a CD56+ natural killer cell phenotype and the t(2;5)(p23;q35) translocation. After excision, the patient has been free of disease for 44 months. Primary cutaneous CD30+ large cell lymphoma is uncommon in children. To our knowledge, primary cutaneous CD30+ natural killer type lymphoma has not been reported previously. The indolent behavior of this tumor indicates its similarity to other primary cutaneous CD30+ large cell lymphomas and its difference from other CD56+ lymphomas involving the skin, which often exhibit an aggressive clinical course. Cases such as this one illustrate why the use of a single, or even a few, immunohistochemical stains can be misleading in regard to lymphoma classification and prognostication. |
| Databáze: | OpenAIRE |
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