Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
| Autor: | Rakesh Ganguly, Lit-Hsin Loo, Kiat Hwa Chan, Weng Kee Leong, Richard D. Webster, Jia-Ying Joey Lee, Zhen Xuan Wong, Zhiyong Lam, Jia Wen Kong |
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| Přispěvatelé: | School of Physical and Mathematical Sciences |
| Rok vydání: | 2021 |
| Předmět: |
Cluster chemistry
Toxicity Metal carbonyl cluster Cells General Chemical Engineering chemistry.chemical_element Metal carbonyl General Chemistry Medicinal chemistry Article Chemistry chemistry.chemical_compound chemistry Metals Cell culture Apoptosis Carbonyls Chemistry [Science] Osmium skin and connective tissue diseases Mode of action Cytotoxicity QD1-999 Boronic acid |
| Zdroj: | ACS Omega, Vol 6, Iss 43, Pp 29045-29053 (2021) ACS Omega |
| ISSN: | 2470-1343 |
| Popis: | A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death. Ministry of Education (MOE) Nanyang Technological University Published version This work was supported by Nanyang Technological University and the Ministry of Education (Research grant no. RG121/18). |
| Databáze: | OpenAIRE |
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