Glycohistochemical characterization of histologically normal nasal mucosa and enzootic nasal tumor of sheep
| Autor: | Luca Mechelli, Paola Scocco, Giovanni Vitellozzi, Piero Ceccarelli, Francesca Mercati, Elvio Lepri |
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| Rok vydání: | 2012 |
| Předmět: |
Nasal tumor
Pathology medicine.medical_specialty SURFACE Glycoconjugate Nose Neoplasms education DIVERSITY Sheep Diseases Mucous membrane of nose Adenocarcinoma Betaretrovirus Glycosaminoglycan GOATS Lectins otorhinolaryngologic diseases Chemical groups medicine Animals INTRANASAL TUMOR LECTIN HISTOCHEMISTRY SUBMANDIBULAR-GLAND VIRUS EQUINE GLYCOPROTEIN FETAL chemistry.chemical_classification Sheep General Veterinary biology Histocytochemistry Lectin General Medicine Anatomy Nasal Mucosa Tumor Virus Infections Tissue sections chemistry biology.protein Enzootic Glycoconjugates Retroviridae Infections |
| Zdroj: | American Journal of Veterinary Research. 73:1128-1136 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.73.8.1128 |
| Popis: | Objective—To determine glycohistochemical characteristics of enzootic nasal tumors (ENTs) of sheep, compare results for ENT with those of histologically normal nasal mucosa of sheep, and identify the histologic origin of ENT. Sample—ENT and nasal mucosa samples obtained from cadavers of 5 adult Lacaune sheep with ENT and 5 Lacaune sheep unaffected by ENT, respectively. Procedures—Samples of ENT and nasal mucosa were collected from cadavers of sheep and sectioned. Conventional and lectin histochemical analyses were used to identify glycoconjugates in tissue sections on the basis of their principal chemical groups and principal terminal or internal oligosaccharidic glucidic residues, respectively. Results—ENTs had papillary and tubular portions. Cells in the papillary portion of ENTs had secretion and surface glycoconjugates, which included sulfated glycosaminoglycans and neutral and sialilated glycoproteins. Cells in the tubular portion of ENTs had surface glycoconjugates, which included neutral and sialilated glycoproteins. Both portions of ENTs had C4-acetylated sialoderivatives that were not detected in sections of histologically normal nasal mucosa. Conclusions and Clinical Relevance—The papillary portion of ENTs in sheep may originate from respiratory glands and goblet cells. The tubular portion of ENTs in sheep may originate from olfactory glands. Presence of C4-acetylated sialoderivatives in cells of ENTs could confer resistance against pathogens to those cells. |
| Databáze: | OpenAIRE |
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