Immunocompetence of sheep experimentally infected with bovine leukemia virus
| Autor: | D. Levy, A L Parodi, G.L. Cockerell |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Dinitrobenzene animal diseases viruses Immunology Sheep Diseases Antibodies Viral chemistry.chemical_compound Antigen Leukemia Virus Bovine Animals Seroconversion Immunity Cellular Leukemia Experimental Sheep General Veterinary Bovine leukemia virus biology Pokeweed mitogen biology.organism_classification Virology chemistry Immunization Concanavalin A Antibody Formation biology.protein Immunocompetence |
| Zdroj: | Veterinary immunology and immunopathology. 13(3) |
| ISSN: | 0165-2427 |
| Popis: | The humoral and cellular immunological reactivity of sheep were studied throughout the first 32 weeks following experimental infection with bovine leukemia virus (BLV). Seroconversion of BLV-inoculated sheep occurred within 4 weeks, but infection was not transmitted to contact control sheep. Despite the persistence of the viral infection, no differences were demonstrated in leukograms, serum IgG concentrations, humoral response to immunization with an irrelevant antigen (rabbit red blood cells), phytomitogen (Concanavalin A and Pokeweed mitogen)-induced lymphocyte blastogenesis, or chemical (1-chloro, 2–4 dinitrobenzene) skin contact hypersensitivity, between BLV-infected and uninfected contact control sheep. These results demonstrate the absence of a nonspecific immunosuppressive effect of BLV and further negate the influence of a generalized immunological deficit on the development of clinical disease in BLV-infected animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|