Association Between Severity of Anaphylaxis and Co-occurrence of Respiratory Diseases: A Systematic Review and Meta-analysis of Observational Studies
| Autor: | Miguel A. Tejedor-Alonso, E Pérez-Fernández, S Perez-Codesido, Mar Moro-Moro, N Alberti Masgrau, M Privitera-Torres, E Farias-Aquino, A Rosado-Ingelmo |
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| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
medicine.medical_specialty Immunology MEDLINE macromolecular substances Severity of Illness Index Pulmonary Disease Chronic Obstructive Internal medicine medicine Humans Immunology and Allergy Respiratory system Anaphylaxis Asthma COPD business.industry musculoskeletal neural and ocular physiology Respiratory disease medicine.disease respiratory tract diseases nervous system Meta-analysis Observational study business |
| Zdroj: | Journal of Investigational Allergology and Clinical Immunology. 31:132-144 |
| ISSN: | 1018-9068 |
| DOI: | 10.18176/jiaci.0462 |
| Popis: | Background and objective Asthma is very prevalent in all grades of severity of anaphylaxis. Asthma and chronic obstructive pulmonary disease (COPD) have been associated with the severity of anaphylaxis. Objective: We carried out a systematic review and meta-analysis to assess the influence of respiratory diseases on the severity of anaphylaxis. Methods We searched PubMed/MEDLINE, EMBASE, and the Web of Science for observational studies. The target studies were those that compared the severity of anaphylaxis between patients who had or did not have respiratory diseases. Results A total of 13 studies assessed the severity of anaphylaxis in respiratory disease. Respiratory disease increased the severity of anaphylaxis (OR, 1.87; 95%CI, 1.30-2.70), as did asthma (OR, 1.89; 95%CI, 1.26-2.83). For the meta-analysis of all studies (adjusted and nonadjusted), COPD increased the severity of anaphylaxis (OR, 2.47; 95%CI, 1.46-4.18). In the case of asthma studies, only 1 study assessed the influence of severity of asthma on severity of anaphylaxis. Conclusions Evidence showing that respiratory disease increases the severity of anaphylaxis is low to moderate, although studies do not usually assess the importance of severity of asthma. |
| Databáze: | OpenAIRE |
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