Plasma free iron: a possible cause of oedema in kwashiorkor
| Autor: | H Malan, H D Heese, Rosseau S, A. A. Sive, W S Dempster |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Iron Serum albumin Gastroenterology Teaching hospital Edema Internal medicine Blood plasma medicine Humans Child Serum Albumin chemistry.chemical_classification biology business.industry Transferrin Kwashiorkor Infant Original Articles medicine.disease Malnutrition Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health biology.protein Etiology medicine.symptom business |
| Zdroj: | Archives of Disease in Childhood. 76:54-56 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.76.1.54 |
| Popis: | Accepted 22 October 1996 BACKGROUND—Oedema is a sine qua non for the diagnosis of kwashiorkor yet the mechanisms leading to oedema remain ill defined. AIMS—To relate the plasma concentration of radical promoting `free' iron to the degree of oedema in patients with kwashiorkor. SETTING—University teaching hospital. PATIENTS—Fifteen children with kwashiorkor, nine of whom had severe and six of whom had a moderate degree of oedema. METHODS—Plasma `free' iron was measured as bleomycin detectable iron (BDI) and related to severity of oedema and plasma albumin concentration. RESULTS—BDI was significantly higher in the patients with severe oedema (20.5 v 6.75 µmol/l) whereas the albumin concentrations were similar (16 v 17 g/l). BDI was no longer present in any patients 30 days after admission. CONCLUSIONS—`Free' circulating iron may contribute to the oedema of kwashiorkor, and its sequestration could hasten recovery and decrease morbidity and mortality. |
| Databáze: | OpenAIRE |
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