Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis
| Autor: | Marcel A. de Reus, Jan H. Veldink, Ruben Schmidt, Leonard H. van den Berg, Martijn P. van den Heuvel, Esther Verstraete |
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| Přispěvatelé: | Human genetics |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male amyotrophic lateral sclerosis Pathology medicine.medical_specialty Degeneration (medical) Brain mapping Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine resting-state Neural Pathways diffusion weighted imaging medicine Humans Radiology Nuclear Medicine and imaging Amyotrophic lateral sclerosis Research Articles Aged 030304 developmental biology Brain Mapping 0303 health sciences Radiological and Ultrasound Technology Resting state fMRI medicine.diagnostic_test Motor Cortex Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging 3. Good health Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Neurology connectivity Female Neurology (clinical) Anatomy Psychology Neuroscience 030217 neurology & neurosurgery Diffusion MRI Motor cortex |
| Zdroj: | Schmidt, R, Verstraete, E, de Reus, M A, Veldink, J H, van den Berg, L H & van den Heuvel, M P 2014, ' Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis ', Human Brain Mapping, vol. 35, no. 9, pp. 4386-4395 . https://doi.org/10.1002/hbm.22481 Human Brain Mapping, 35(9), 4386-4395. Wiley-Liss Inc. Human Brain Mapping |
| ISSN: | 1097-0193 1065-9471 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive loss of motor function. While the pathogenesis of ALS remains largely unknown, imaging studies of the brain should lead to more insight into structural and functional disease effects on the brain network, which may provide valuable information on the underlying disease process. This study investigates the correlation between changes in structural connectivity (SC) and functional connectivity (FC) of the brain network in ALS. Structural reconstructions of the brain network, derived from diffusion weighted imaging (DWI), were obtained from 64 patients and 27 healthy controls. Functional interactions between brain regions were derived from resting-state fMRI. Our results show that (i) the most structurally affected connections considerably overlap with the most functionally impaired connections, (ii) direct connections of the motor cortex are both structurally and functionally more affected than connections at greater topological distance from the motor cortex, and (iii) there is a strong positive correlation between changes in SC and FC averaged per brain region (r = 0.44, P < 0.0001). Our findings indicate that structural and functional network degeneration in ALS is coupled, suggesting the pathogenic process affects both SC and FC of the brain, with the most prominent effects in SC. Hum Brain Mapp 35:4386–4395, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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