Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients
| Autor: | Frank Lammert, Sigrun Smola, Stephan Stilgenbauer, Philipp M. Lepper, Yvonne Bewarder, Andreas Link, Manfred Ahlgrimm, Stefan Wagenpfeil, Marcin Krawczyk, Martina Seiffert, Joerg Thomas Bittenbring, Frank Neumann, Benedikt Balensiefer, Lorenz Thurner, Dominic Kaddu-Mulindwa, Vadim Lesan, Igor Kos, Konstantin Christofyllakis, Torben Rixecker, Moritz Bewarder, Robert Bals |
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| Rok vydání: | 2021 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male medicine.medical_specialty Immunology Immunity to infection CD8-Positive T-Lymphocytes Biology Antibodies Viral Severity of Illness Index Gastroenterology Monocytes law.invention Pathogenesis Clinical Immune system law Internal medicine medicine Humans Immunology and Allergy Autoimmunity ⋅ B/T‐cell ratio ⋅ COVID‐19 ⋅ Lymphocytes ⋅ Monocytes Lymphocyte Count Prospective Studies Prospective cohort study Research Articles B cell Aged B-Lymphocytes Research Article|Clinical SARS-CoV-2 Monocyte COVID-19 Middle Aged Intensive care unit medicine.anatomical_structure Immunoglobulin G Cohort Female CD8 |
| Zdroj: | European Journal of Immunology |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.202049163 |
| Popis: | The pathogenesis of autoimmune complications triggered by SARS‐CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID‐19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID‐19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T‐cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4+T, CD8+T‐lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8‐cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID‐19. Both parameters were associated with death in cohort 1. Patients with severe COVID‐19 present a particular set of immune changes in comparison to patients with mild disease and controls. These include consumption of certain monocyte and lymphocyte populations and an elevated B/T8 Ratio. COVID‐19 patients in general share a proinflammatory immunoglobulin profile with elevated proportions of IgG1 and/or IgG3. |
| Databáze: | OpenAIRE |
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